DNS configuration to invoke complete URL (no replies)

Hi Talents,
Need your support immediately on the below requirement:

I have configure DNS "worsktream.com" to proxy pass the complete URL "http://worsktream.com/workstream/agentLogin"
while invoking the dns name following message is thrown:
- error 414 Request-URI Too Large

And after configuring following to fix the above issue
syntax: large_client_header_buffers number size
default: large_client_header_buffers 4 4k/8k

Now, the below issue is reported
- nginx accept() failed (24 too many open files)

I could see the logs are getting piled up with so many hits on the request URL. Indefinite loop is seen.

Please suggest to resolve this.

Best regards,
Maddy