nginx reverse proxy causing TCP queuing spikes (no replies)

I've been struggling with http response time slowdowns and
corresponding spikes in my TCP Queuing graph in munin. I'm using
nginx as a reverse proxy to apache which then hands off to my backend,
and I think the proxy_read_timeout line in my nginx config is at least
contributing to the issue. Here is all of my proxy config:

proxy_read_timeout 60m;
proxy_pass http://127.0.0.1:8080;

I think this means I'm leaving connections open for 60 minutes after
the last server response which sounds like a bad thing. However, some
of my admin pages need to run for a long time while they wait for the
server-side stuff to execute. I only use the proxy_read_timeout
directive on my admin locations and I'm experiencing the TCP spikes
and http slowdowns during the exact hours that the admin stuff is in
use.

- Grant

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